FBS Processing Charts

The ISIA Fetal Bovine Serum (FBS) Processing Charts provide a clear, step-by-step overview of the critical stages involved in producing high-quality, ethically sourced serum for global research and biomanufacturing. These charts are designed to support transparency, strengthen understanding of industry best practices, and reinforce the importance of robust quality and traceability systems.

  • This chart outlines the initial stage of the process, detailing proper animal handling, hygienic collection techniques, and documentation practices that ensure traceability and regulatory compliance from the very start. Click here to view the chart

  • An overview of criteria used to evaluate and select raw serum—including origin verification, quality characteristics, and compliance with ISIA standards—ensuring only suitable materials enter the process. Click here to view the chart

  • This chart highlights the temperature-controlled logistics required to preserve serum integrity during transport and storage, from collection through processing. Click here to view the chart

  • A step-by-step view of the controlled centrifugation and handling procedures needed to separate serum cleanly and safely from whole blood while preventing contamination. Click here to view the chart

  • An explanation of proper thawing methods used to maintain product quality and avoid degradation before downstream processing steps. Click here to view the chart

  • This chart shows how individual serum lots are pooled under controlled conditions and subjected to initial filtration steps to prepare the material for sterile processing. Click here to view the chart

  • An overview of the cleanroom environment, sterile filtration, and aseptic handling practices used to fill final containers while maintaining product sterility and consistency. Click here to view the chart

  • The final chart summarizes end-stage processing, quality control testing, packaging, labeling, and documentation required to release a compliant, traceable, and high-quality FBS product. Click here to view the chart